Do not take this drug right before or after heart bypass surgery CABG. Talk to your doctor or pharmacist about the benefits and risks of treatment, as well as other possible medication choices.
See also Precautions section. Before using this medication, women of childbearing age should talk with their doctor s about the benefits and risks. Tell your doctor if you are pregnant or if you plan to become pregnant. It is not recommended for use in pregnancy from 20 weeks until delivery.
If your doctor decides that you need to use this medication between 20 and 30 weeks of pregnancy, you should use the lowest effective dose for the shortest possible time. You should not use this medication after 30 weeks of pregnancy. Babies born to mothers who use this drug for a long time may develop severe possibly fatal withdrawal symptoms.
This combination medication is used for a short time usually less than 10 days to help relieve moderate to severe pain. It contains an opioid pain reliever hydrocodone and a nonsteroidal anti-inflammatory drug-NSAID ibuprofen. Hydrocodone works in the brain to change how your body feels and responds to pain. Ibuprofen reduces pain and fever. Read the Medication Guide provided by your pharmacist before you start using this medication and each time you get a refill.
If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually every 4 to 6 hours as needed. Take it with a full glass of water 8 ounces or milliliters unless your doctor directs you otherwise.
Do not lie down for at least 10 minutes after taking this drug. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea such as lying down for 1 to 2 hours with as little head movement as possible.
The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose, take the medication more frequently, or take it for a longer time than prescribed.
Properly stop the medication when so directed. The manufacturer recommends you take no more than 5 tablets in a hour period. Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well. Also follow your doctor's or pharmacist's directions for the safe use of other non-opioid pain relievers such as acetaminophen. Suddenly stopping this medication may cause withdrawal, especially if you have used it for a long time or in high doses.
To prevent withdrawal, your doctor may lower your dose slowly. When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well. Though it helps many people, this medication may sometimes cause addiction. Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details. Upset stomach, nausea, vomiting, constipation, dizziness, lightheadedness, or drowsiness may occur.
If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Mean pain intensity difference PID scores were similar for hydrocodone with ibuprofen and oxycodone with acetaminophen at 0. The sum of the PID scores was similar for hydrocodone with ibuprofen and oxycodone with acetaminophen for the 0- to 3-, 0- to 4-, 0- to 6-, and 0- to 8-hour intervals.
The median estimated time to onset of analgesia, mean peak PR score, median time to remedication, and mean global assessment score were similar for hydrocodone with ibuprofen and oxycodone with acetaminophen.
Ask a doctor before using this medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby. Follow the directions on your prescription label and read all medication guides. Never use this medicine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine. Never share this medicine with another person, especially someone with a history of drug abuse or addiction.
Selling or giving away this medicine is against the law. Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.
Since hydrocodone and ibuprofen is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.
Seek emergency medical attention or call the Poison Help line at An overdose can be fatal, especially in a child or other person using the medicine without a prescription.
Overdose symptoms may include black or bloody stools, coughing up blood, severe drowsiness, pinpoint pupils, slow breathing, or no breathing. Your doctor may recommend you get naloxone a medicine to reverse an opioid overdose and keep it with you at all times.
A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR cardiopulmonary resuscitation on you while waiting for help to arrive. Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. They may contain ingredients similar to ibuprofen such as aspirin, ketoprofen, or naproxen.
Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling.
Despite the inactivity of ibuprofen alone in this model, the inclusion of ibuprofen with hydrocodone markedly enhanced the analgesic response. Using a fixed hydrocodone:ibuprofen ratio also revealed a marked four-fold shift to 2. These findings suggest a synergistic interaction between ibuprofen and hydrocodone in a noninflammatory pain model.
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